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Enhanced Remineralisation of Tooth Enamel Using Casein Phosphopeptide-Amorphous Calcium Phosphate Complex: A Review
Int J Clin Prev Dent 2018;14(1):1-10
Published online March 31, 2018;
© 2018 International Journal of Clinical Preventive Dentistry.

Nidhi Chhabra, Anuj Chhabra

Department of Dental Surgery, North DMC Medical College and Hindu Rao Hospital, Delhi, India
Correspondence to:
Nidhi Chhabra
Department of Dental Surgery, North DMC Medical College and Hindu Rao Hospital, DR. J.S. Kkaranwal Memorial Road, Near Malka Ganj, Sabji Mandi, Malka Ganj, New Delhi, Delhi 110007, India. 
Tel: +91-1127471245, Fax: +91-1127471245, E-mail:
Received February 28, 2018; Revised March 5, 2018; Accepted March 9, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The protective effects of milk and milk products against dental caries, due to micellar casein or caseinopeptide derivatives, have been demonstrated in various animal and human in situ studies. Among all the remineralising agents, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) technology has shown the most promising scientific evidence to support its use in prevention and reversal of carious lesions. CPP-ACP complex acts as a calcium phosphate reservoir and buffer the activities of free calcium and phosphate ions in the plaque. Calcium phosphate stabilized by CPP produces a metastable solution supersaturated with respect to the amorphous and crystalline calcium phosphate phases, thereby depressing enamel demineralisation and enhancing mineralisation. CPP-ACP provides new avenue for the remineralisation of noncavitated caries lesions. The objective of this article was to review the clinical trials of CPP-ACP complex and highlight its evidence based applications in dentistry. 
Keywords : remineralisation, casein derivatives, casein phospho peptide-amorphous calcium phosphate
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