Stabilization of Zinc Ions and Potassium Phosphates Using Milk Protein Hydrolysates and In-Vitro Evaluation of Dentinal Tubule Occlusion
Jong Hyun Lim, Kyo-Tae Moon, Kyounghee Oh, Wonho Ha
R&D Center, LG H&H, Seoul, Korea
Received November 15, 2024; Revised November 23, 2024; Accepted December 3, 2024.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- Objective: In this study, we propose a method to stabilize ZnCl2 and potassium phosphates using milk protein hydrolysates (MPHs) to develop a dentifrice that alleviates dentin hypersensitivity.
Methods: The changes in particle size of dispersions containing ZnCl2, KH2PO4, K2HPO4, and MPHs in aqueous solutions were monitored, and the interactions between each component were identified. A dentifrice containing a stabilized complex of ZnCl2, potassium phosphates and MPHs was prepared, and its efficacy to inhibit dentin permeability was quantitatively demonstrated.
Results: ZnCl2, KH2PO4, K2HPO4, and MPHs spontaneously formed nanocomplexes in aqueous solutions. These complexes rapidly aggregated upon contact with hydroxyapatite. The aggregation resulted in effective dentinal tubule occlusion and provided high acid resistance.
Conclusion: The dentifrice containing a complex of ZnCl2, potassium phosphates and MPHs has been shown to have the efficacy of occluding dentinal tubules and may help relieve dentin hypersensitivity. - Keywords : dentifrice, dentin hypersensitivity, milk protein hydrolysate, potassium phosphate, zinc
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