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Antibacterial effect of mouthwash containing CPC against dental caries caused bacteria
Int J Clin Prev Dent 2021;17(3):149-149
Published online September 30, 2021;
© 2021 International Journal of Clinical Preventive Dentistry.

Won-Ho Cho1, Ja-Won Cho1, Hyun-Jun Yoo1, Kyong-Hoon Shin2, Gi-Hae Shin2, Yeol-Mae Jeon1, Jong-Cheon Lee1

1Department of Preventive Dentistry, College of Dentistry, Dankook University, Cheonan,
2Aekyung Industrial Co., Ltd. R&D Division Dental Care Team, Daejeon, Republic of Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objectives: The purpose of this study was to evaluate and report the antibacterial efficacy in relation to oral disease-causing bacteria using a mouthwash containing 0.05% CPC in an in vitro test.
Methods: The sterilization test and susceptibility assay of mouthwash containing 0.05% CPC were investigated against Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus; Streptococcus sanguinis as oral bacteria related to dental caries; Enterococcus faecalis as apical periodontitis-related bacteria; and Actinomyces israelii, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescence, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Filifactor alocis as periodontal disease-related bac-teria.
Results: In the sterilization test, most of the bacteria had more than 99.99% sterilizing power for all samples but compared to other bacteria, the sterilizing power of these samples was not successful for L. acidophilus and E. faecalis bacteria. When comparing the sterilization power between the samples, sample 3 (0.05% CPC+20% ethanol) was the strongest.
Conclusions: In the antimicrobial activity test, sample 3 inhibited growth at the lowest concentration overall.
Keywords : Cetylpyridinium chloride, Mouthwashes, Streptococcus mutans

September 2021, 17 (3)