search for


Desensitization Effects by Night Time Using of a Dentifrice Containing Calcium Glycerophosphate before Bedtime
Int J Clin Prev Dent 2017;13(4):165-170
Published online December 31, 2017;
© 2017 International Journal of Clinical Preventive Dentistry.

Ha-Na Song1, Ji-Hyeon Park2, Ja-Won Cho3

1Department of Dentistry, Daejeon Hankook Hospital, Daejeon, 2Department of Dental Hygiene, Gangneung Yeongdong University, Gangneung, 3Department of Preventive Dentistry, College of Dentistry, Dankook University, Cheonan, Korea
Correspondence to: Ji-Hyeon Park
Department of Dental Hygiene, Gangneung Yeongdong University, 357 Gongje-ro, Gangneung 25521, Korea. 
Tel: +82-33-610-0420, Fax: +82-33-610-0323, E-mail:
Received November 12, 2017; Revised December 13, 2017; Accepted December 13, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: The aim of this clinical study was to determine the desensitization effect of the calcium glycerophosphate-containing dentifrice at bed time.Methods: Patients with symptoms of mild to severe dentin hypersensitivity between 20 and 40 years of age were allocated into two groups; the experimental group and the control group. Each group had used the dentifrice containing or excluding calcium glycerophosphate for 3 weeks. Symptoms of all participants were measured at baseline, after 3 days, 5 days, 1 week, 2 weeks and 3 weeks by the air blow method and the electric pulp tester (EPT).Results: Symptoms of dentin hypersensitivity measured by the air blow method decreased in the experimental group (from 6.03 at baseline to 5.85 at 3 days, 5.36 at 5 days, 5.09 at 1 week, and 4.75 at 2 weeks) and there was a significant difference in the reduction effect after 5 days (p<0.05). With the EPT method, there was a statistically significant difference in the hypersensitivity reduction effect in the experimental group after 1 week (from 18.80 at baseline to 18.80 at 3 days, 19.17 at 5 days, 21.33 at 1 week, and 22.30 at 2 weeks, p<0.05).Conclusion: The use of a dentifrice containing calcium glycerophosphate at bedtime produced significant reductions in hypersensitivity and rapid effects in relieving hyperesthesia, compared with the control group.
Keywords : dentifrices, glycerophosphate, dentin sensitivity, dental pulp test, toothbrushing
  1. Kim JB. Preventive dentistry. 3rd ed. Seoul: Komoonsa; 2000: 202-23.
  2. Kim JB, Choi EG. Public oral health. 3rd ed. Seoul: Komoonsa; 1991:197-209.
  3. Bernier JL, Muhler JC. Improving dental practice through preventive measure. 3rd ed. St. Louis: Mosby; 1975:118.
  4. Addy M, Urquhart E. Dentine hypersensitivity: its prevalence, aetiology and clinical management. Dent Update 1992;19:407- 8, 410-2.
  5. Pashley DH. Dentin-predentin complex and its permeability: physiologic overview. J Dent Res 1985;64 Spec No:613-20.
  6. Uchida A, Wakano Y, Fukuyama O, Miki T, Iwayama Y, Okada H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. J Periodontol 1980;51:578-81.
  7. Lee SY, Kwon HK, Kim BI. Occluding effect of dentinal tubule and sustaining power with dentifrice containing nano-carbonate apatite. J Korean Acad Oral Health 2011;35:388-95.
  8. Bowen WH. The cariostatic effect of calcium glycerophosphate in monkeys (M. irus). Caries Res 1971;5:7.
  9. Brook AH, Gawthorpe J, Winter GB. Calcium glycerophosphate and dental plaque. Clinical pilot study. Caries Res 1975;9:156- 62.
  10. Canadian Advisory Board on Dentin Hypersensitivity. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc 2003;69: 221-6.
  11. Brännström M. The cause of postrestorative sensitivity and its prevention. J Endod 1986;12:475-81.
  12. Lee SY, Kwon HK, Kim BI. Effect of dentinal tubule occlusion by dentifrice containing nano-carbonate apatite. J Oral Rehabil 2008;35:847-53.
  13. Louis I, Grossman DDS. A systematic method for the treatment of hypersensitive dentin. J Am Dent Assoc 1935;22:592-602.
  14. Pashley DH. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med 1996;7:104-33.
  15. Jang SO, Kim DG, Ko YM. Clinical evaluation of dentinal hypersensitivity treatment containing Potassium phosphate and Ursodexoxycholic acid. J Korea Res Soc Dent Mat 2007;34: 89-97.
  16. Son JB, Seong JH, Kim DG. Desensitizing effect of toothpaste containing potassium phosphate on dentinal hypersensitivity. J Korean Acad Oral Health 2003;27:97-111.
  17. Duke SA, Rees DA, Forward GC. Increased plaque calcium and phosphorus concentrations after using a calcium carbonate toothpaste containing calcium glycerophosphate and sodium monofluorophosphate. Pilot study. Caries Res 1979;13:57-9.
  18. Sidi AD. Effect of brushing with fluoride toothpastes on the fluoride, calcium, and inorganic phosphorus concentrations in approximal plaque of young adults. Caries Res 1989;23:268-71.
  19. Sidi AD, Wilson RF. Fluoride, calcium and inorganic phosphorus concentrations in approximal plaque collected from young adults 1 and 24 h after toothbrushing with fluoride toothpastes. Caries Res 1991;25:330-4.
  20. Lee HW, Cho EJ, Shin KH, Koo HS, Cho IS, Cho JW. A clinical study on the desensitization effect by use of calcium-glycerophosphate-containing dentifrice. Int J Clin Prev Dent 2016;12: 103-9.
  21. Kim JH, Kim SU, Kwon YH, Lee MS. Clinical evaluation of microcrystalline hydroxyapatite toothpaste in the control of dentin hypersensitivity. J Korean Acad Periodontol 1984;14:229-40.

December 2018, 14 (4)