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The Influence for the Early Stage of the Gingivitis, by Use of the Dentifrice Contained with Panax notoginseng, Magnoliae Cortex, and Tranexamic Acid
Int J Clin Prev Dent 2017;13(3):117-122
Published online September 30, 2017;
© 2017 International Journal of Clinical Preventive Dentistry.

Sun-Joo Yoon, Kyung-Hui Moon, Ji-Young Lee, Mi-Kyoung Jeong

Department of Dental Hygiene, Jinju Helth College, Jinju, Korea
Correspondence to: Sun-Joo Yoon
Department of Dental Hygiene, Jinju Helth College, 51 Uibyeong-ro, Jinju 52655, Korea. Tel: +82-55-740-1840, Fax: +82-030300081840, E-mail:
Received June 9, 2017; Revised June 26, 2017; Accepted September 20, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: This study was conducted to compare the effects of dentifrice containing dentifrice components such as Panax notoginseng, Magnoliae Cortex and tranexamic acid and bamboo salt on the periodontal tissues such as relief of initial gingivitis and mitigation of gingival bleeding. I would like to use it as a reference for the development of dentifrice for patients with
periodontal diseases.
Methods: 20 applicants who had a slight gingivitis have participated in this study by dividing 4 groups as using the dentifrice in the Panax notoginseng, Magnoliae Cortex, tranexamic acid and bamboo salt, were used for four weeks. PHP (patient hygiene performance) index, GBI (gingival bleeding) index, coated tongue check, oral moisture check were performed on before the experiment, a week later, 2 weeks and 4 weeks later. The data were analyse in order to compare the results for the gingival subside effect.
Results: GBI index, and coated tongue index were significantly different in all experimental groups (p<0.05), and there was a significant difference in PHP index between the control and experimental 3 groups after one week (p<0.01). oral moisture index was significantly different between the control group and the experimental 3 group (p<0.05). There was no significant difference between two weeks (p>0.05). Halitosis index was not significantly different in all groups (p>0.05).
Conclusion: Using dentifrice containing Panax notoginseng, Magnoliae Cortex, tranexamic acid and bamboo salt were recommended to relieve slight gingivitis.
Keywords : dentifrice, gingival bleeding
  1. Mandel ID. Chemotherapeutic agents for controlling plaque and gingivitis. J Clin Periodontol 1988;15:488-98.
    Pubmed CrossRef
  2. Ciancio SG. Agents for the management of plaque and gingivitis. J Dent Res 1992;71:1450-4.
    Pubmed CrossRef
  3. Kim TI, Yeom HR, Ryu IC, Bae KH, Chung CP. Clinical and microbiological study on the effect of magnoliae cortex and ginkgo biloba extracts containing dentifrice in gingivitis. J Pharm Sci 1996;12:140-54.
  4. Lee YM, Ku Y, Bae KH, Chung CP. Tissue regenerative activity of Magnolia and Zizyphi fructus extract mixtures. J Korean Acad Periodontol 1997;27:165-77.
  5. Gang IG, Lee SC, Chung CP, Son SH. Studies on the clinical and microbiological effect of toothpaste containing the aefolium, myrrha, moriradicis and cimicifugae rhizma extract. J Korean Acad Periodont 1991;21:1-16.
  6. Ministry of Food and Drug Safety. Korean traditional oriental medicine standard house. Cheongju: Dongwon Culture Co., Ltd; 2007:184.
  7. Bae KH. Health sciences division. Seoul: Kyohaksa; 2003:245.
  8. Komakine N, Okasaka M, Takaishi Y, Kawazoe K, Murakami K, Yamasa Y. New dammarane-type saponin from roots of Panax notoginseng. J Nat Med 2006;60:135-7.
  9. Park YK, Jung HW. Panax notoginseng inhibits LPS-induced pro-inflammatory mediators in microglia. Korean J Herbol 2006;21:93-101.
  10. Ng TB. Pharmacological activity of sanchi ginseng (Panax notoginseng). J Pharm Pharmacol 2006;58:1007-19.
    Pubmed CrossRef
  11. Chung CP, Ku Y, Bae KH. Biological effect of magnolia and ginkgo biloba extract to the antimicrobial, antiinflammatory and cellular activity. J Pharm Sci 1995;11:101-9.
  12. Rubin E, Farber JL. Pathology. Philadelphia: J.B. Lippincott Co.; 1988:43.
  13. Oh HN, Choi CH. Effect of bamboo salt on human gingival fibroblasts. J Korean Acad Oral Health 2014;38:90-4.
  14. Kim CY, Chung SC, Sohn WS. Comparison of the anti-plaque and anti-inflammatory effect of the dentifrices contatining NaCl and bamboo salt. J Korean Acad Dent Health 1991;15:269-80.
  15. Paik DI, Kim HD, Jin BH, Park YD, Shin SC, Cho JW, et al. Clinical preventive dentistry. 5th ed. Seoul: Komoonsa; 2011: 32-300.
  16. Addy M, Willis L, Moran J. Effect of toothpaste rinses compared with chlorhexidine on plaque formation during a 4-day period. J Clin Periodontol 1983;10:89-99.
    Pubmed CrossRef
  17. Mankodi S, Walker C, Conforti N, DeVizio W, McCool JJ, Volpe AR. Clinical effect of a triclosan-containing dentifrice on plaque and gingivitis: a six-month study. Clin Prev Dent 1992;14:4-10.
  18. Min BS, Choi HY, Choi YJ, Hong JP , Chun YH, Kang NH. The reducing effects on dental plaque formation and gingivitis of toothpastes containing bamboo salt and several herb medicines. J Korean Dent Asso 1996;34:65-71.
  19. Park KI, Choi EG. A clinical study on the effect of dentifrice containing some oriental medicine and bamboo salt. J Korean Acad Oral Health 1994;18:390-400.
  20. Busuttil SJ, Ploplis VA, Castellino FJ, Tang L, Eaton JW, Plow EF. A central role for plasminogen in the inflammatory response to biomaterials. J Thromb Haemost 2004;2:1798-805.
    Pubmed CrossRef
  21. Jang BS, Chung CP, Son SH, Bae KH. The effects of honokiol and magnolol on the antimicrobial, bacterial collagenase activity, cytotoxicity and cytokine production. J Korean Acad Periodont 1993;23:145-58.
  22. Lee DJ, Han IM, Kim WJ, Cho IS. Anti-microbial, anti-inflammatory and anti-oxidative effects of herbal medicine extracts as anti-gingivitis ingredients. J Dent Hyg Sci 2010;10: 25-9.

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